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We report a case of an acute ST-segment elevation myocardial infarction in a patient with traditional cardiac risk factors using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient also had polycythemia, likely secondary to high-dose testosterone. The patient underwent profitable percutaneous intervention of the proper coronary artery. Physicians and sufferers ought to concentrate on the clinical consequences of anabolic steroid abuse.
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Unfortunately, the info on the use of high dose anabolic steroids in people are mainly supplied as case stories or small research that lack enough control groups. In addition, the information available within the literature does not account for the steroid sort or dose, as neither could also be known. Patients additionally could also be taking concomitant stimulants, corresponding to ephedra, which can confound knowledge and the potential for antagonistic occasions. It is probably going that the frequency of cardiac occasions is underreported within the medical literature. Supraphysiologic doses of anabolic-androgenic steroids , which embody greater than 30 pure and synthetic derivatives of testosterone, may cause a large spectrum of clinical sequalae.
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Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a part of endothelial dysfunction has been proposed, which can contribute to irregular vessel reactivity. However, testosterone in physiologic doses may even be helpful in patients with angina , have higher ischemic thresholds and improved high quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood circulate in men with established coronary artery illness .
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